Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor
نویسندگان
چکیده
منابع مشابه
Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor.
BACKGROUND Prostaglandin E2 (PGE2) EP receptors EP3 and EP4 signal via decreased and increased cAMP production, respectively. Previously, we reported that cardiomyocyte-specific EP4 knockout mice develop dilated cardiomyopathy with reduced ejection fraction. Thus, we hypothesized that PGE2 increases contractility via EP4 but decreases contractility via EP3. METHODS AND RESULTS The effects of ...
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ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2016
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.116.003291